Joshua Weiner

IBA Executive Committee Member; IBA-MARC Core Mentor
Professor; Associate Dean for Research, CLAS
Associate Director, Iowa Neuroscience Institute
College of Liberal Arts and Sciences
The University of Iowa
STEM Area of Research: 
Research Interests: 
Cell and Developmental Biology, Neurobiology

Molecular Mechanisms of Neuronal Differentiation and Neural Circuit Formation

The mammalian brain is the most complex system in all of biology. The human brain has ~100 billion neurons and perhaps 500 trillion synapses, contact sites between neurons through which information flows. The differentiation of a vast array of distinct neuronal cell types from stem cell progenitors, and their migration to form layers and clusters, is a key developmental step that can be disrupted in human disorders such as microcephaly and lissencephaly. The elaboration of dendrites and axons and their formation of specific neural circuits underlies all mature function, and dysregulation of these processes underlies a wide variety of genetic and syndromic disorders, including forms of autism spectrum disorders, Down and Fragile X Syndromes, and schizophrenia. My laboratory is focused on identifying the fundamental molecular mechanisms that control neuronal differentiation and neural circuit formation during brain development. We take a candidate approach, generating allelic series of transgenic and knockout mice and analyzing their developmental phenotypes with a wide range of genetic, biochemical, pharmacological, molecular biology, and cell biology techniques. We focus on genes and processes that have been implicated in human neurodevelopmental disorders. Multiple projects are available for ambitious graduate students, postdocs, and undergraduate Honors students. Our work has been continuously funded since the lab’s founding in 2004, including grants from the National Institutes of Health, the March of Dimes, the Carver Trust, the Nellie Ball Trust, the Mallinckrodt Foundation, the E. Matilda Ziegler Foundation for the Blind, and the National Multiple Sclerosis Society.