E. Dale Abel

IBA Core Mentor
Chief, Division of Endocrinology and Metabolism
Professor of Internal Medicine - Endocrinology and Metabolism; Professor of Biochemistry
Department of Internal Medicine
Carver College of Medicine
University of Iowa
MBBS, University of the West Indies, Kingston, Jamaica
PhD, Physiology, Oxford University, UK
4312 PBDB

Our recent studies have underscored the importance of mitochondrial oxidative stress as a major mechanism leading to cardiac dysfunction in obesity and diabetes. Recent studies have focused on: (1) The contribution of excessive myocardial insulin signaling in the myocardium in accelerating left ventricular remodeling in the hypertrophied and failing heart. (2) The regulation of myocardial autophagy by insulin signaling. (3) The mechanisms by which myocardial lipid overload alters autophagy in cardiac muscle (4) The role of altered mitochondrial dynamics in the pathophysiology of cardiac dysfunction in obesity and insulin resistant states. (5) Mechanisms for increased thrombosis in obesity and insulin resistant states.