Michael Duffel

Associate Dean for Research and Graduate Programs, College of Pharmacy
Professor of Medicinal and Natural Products Chemistry, Department of Pharmaceutical Sciences and Experimental Therapeutics
Medical and Natural Products Chemistry
College of Pharmacy
University of Iowa
PhD, Chemistry (Biochemistry), University of Texas at Austin, 1979
BS, Chemistry, University of Texas at Austin, 1975
S325 Pharmacy Building

Dr. Duffel’s current research activities are centered on enzyme-catalyzed reactions that occur with xenobiotics. The major component of this effort includes studies to better understand and predict the role that sulfotransferases play in the cytotoxic, immunologic, mutagenic and carcinogenic responses to drugs, environmental chemicals, and other xenobiotics. One major current research project includes investigations on the mechanism and catalytic regulation of aryl and alcohol sulfotransferases along with development of methods to discover highly selective inhibitors of individual sulfotransferases. Another major research effort is directed towards understanding how polychlorinated biphenyls and their hydroxylated metabolites alter the regulation and catalytic function of the hydroxysteroid sulfotransferases.