Kevin Rice

Professor, Department of Pharmaceutical Sciences and Experimental Therapeutics / Division of Medicinal and Natural Products Chemistry
Department: 
Department of Pharmaceutical Sciences and Experimental Therapeutics
College: 
College of Pharmacy
University: 
The University of Iowa
Education: 
PhD, Medicinal & Natural Products Chemistry, College of Pharmacy, The University of Iowa
BS, Chemistry & Biology, Marycrest College
Phone: 
(319) 335-9903
Research Interests: 
Non-viral gene delivery systems

My laboratory is focused on the development and testing of non-viral gene delivery systems. This typically involves the development of peptides that either bind ionically or covalently to plasmid DNA to direct its targeting across the cell membrane and to the nucleus. We also develop glycopeptides for gene delivery, where the N-glycan mediates cell-specific targeting of DNA and receptor mediated endocytosis. The lab expertise includes solid-phase peptide synthesis, HPLC and MS, plasmid DNA and siRNA formulation, in vitro and in vivo testing of gene delivery systems and bioconjugate chemistry including N-glycan purification and PEGylation of peptides.