The major goal of my research is to develop better treatment options to cure multiple sclerosis (MS). To achieve this goal, my research program focuses on three major interconnected themes: i) utilizing transgenic mice expressing MS susceptible and resistant HLA class II molecules (HLA transgenic mice) to understand the mechanisms of disease pathogenesis; ii) to understand the role of gut microbiome and metabolome in the etiopathogenesis of MS; and iii) test therapeutic efficacy of human gut derived bacteria as drug (BRUG) in animal models of MS.

Research Lab
https://mangalam.lab.uiowa.edu/