Alexander Bassuk

IBA-MARC Core Mentor
Professor of Pediatrics - Neurology
Director, Division of Pediatric Neurology
IBA-MARC Core Mentor; Department of Neurology
Carver College of Medicine
The University of Iowa
STEM Area of Research: 
PhD, Biological Sciences Pathology, University of Chicago
MD, University of Chicago Pritzker School of Medicine
2040 ML

Congenital defects of the nervous system, especially neural tube defects, familial epilepsy, neurogenetics, neural stem cell biology Our laboratory is interested in understanding the basic mechanisms underlying both normal and disordered development of the nervous system. Our approach to these issues includes investigating the genetics of human neural tube defects (NTDs) and familial epilepsies, and elucidating the biology regulating neural stem cell development. The techniques used in our laboratory include genome wide linkage analysis (GWA), association studies, comparative genomic hybridization (CGH), copy number variation (CNV) analysis, transgenic mouse production, and cell culture. As part of our studies we have collected DNA samples from over 2000 patients and family members with congenital nervous system malformations, and several large families with autosomal recessive epilepsy syndromes.